It is a West London derby this Saturday as London Irish make the short trip to Twickenham to take on Harlequins in the Gallagher Premiership. 

Quins have had an inconsistent start to the season, winning three and losing three of their opening six matches and are yet to win consecutive matches this season. 

This has been shown best in the last two games when they were dominated at home by Leicester before going to the previously undefeated Sale Sharks and winning. 

London Irish have also not won back-to-back games as they have only won one match and sit bottom of the Gallagher Premiership. 

These two have already played this season in the Premiership Cup and London Irish won away from home 30-26. 

Kick-off at the Twickenham Stoop is at 3pm on Saturday. 

Ealing Trailfinders face their biggest test of the season so far as they play host to third place Nottingham in the RFU Championship. 

The Trailfinders have been flawless so far this season after winning six games out of six to start the season, but this weekend they face their biggest challengers so far with the four-win Nottingham visiting W13. 

Nottingham have made a solid start to the season and bounced back from a surprising defeat to Hartpury two games ago by dominating Richmond at home last week 45-26. 

Kick-off at Trailfinders Sports Club is at 3pm on Saturday. 

London Welsh are coming off a vital victory last week and will hope to build on that as they head on the road against Banbury this Saturday. 

Welsh ended a four-game losing streak last weekend as they won at Old Deer Park for the first time this season against Bracknell 45-15. 

They know that if they beat the Oxfordshire side this weekend then they would go above them in Regional 1 South Central. 

Banbury are currently on a two-game winning run but have struggled to score points even in victory as they have yet to score 30 points this season. 

Kick-off at Bodicote Park is at 3pm on Saturday. 

Teddington RFC lay their unbeaten record on the line once again as they play away against Effingham and Leatherhead in Counties 2 Surrey. 

The Antlers won a crunch top of the table clash at Bushy Park last weekend against Chipstead to become the last team in the division to be undefeated this season. 

The opponents in Effingham and Leatherhead have just the one win to their name this season and that was their second game of the season against Old Amplefordians back in September. 

Kick-off at King George V Hall is at 3pm on Saturday. 

Elsewhere in the area, London Scottish are away against Cornish Pirates, Richmond host Bedford in the RFU Championship, and Kingston are playing at home against Chobham.